痔病是影响全球人群的常见肛门直肠疾病。患病率高,治疗困难,和可观的治疗费用。与其他治疗方案相比,痔疮的药物治疗危害最小,给病人更多的尊严,而且更经济。不幸的是,临床上很少有化学痔疮药物,这使得寻找有效的,成本效益高,和环境友好型新药类别是研究的重点。在这种情况下,寻找可用的天然产品来改善痔疮显示出巨大的潜力。这些产品来源于大自然,主要来自植物,一小部分来自动物,真菌,和藻类。它们具有优异的凝血途径调节,抗炎,抗菌,和组织再生活动。因此,我们认为它们是一类潜在的痔疮药物,预防产品,和药物附加成分。本文首先回顾了导致痔疮发展的因素,类型,主要症状,以及痔疮天然产物的机理。建立在这个基础上,我们筛选了具有潜在痔疮改善活性的天然产品,包括多酚和类黄酮,萜烯,多糖,和其他类型。
Hemorrhoid disease is a common anorectal disorder affecting populations worldwide, with high prevalence, treatment difficulties, and considerable treatment costs. Compared to other treatment options, medical therapy for
hemorrhoids offers minimal harm, more dignity to patients, and is more economical. Unfortunately, there are few chemical hemorrhoid medications available clinically, which makes the search for efficacious, cost-effective, and environmentally friendly new medication classes a focal point of research. In this context, searching for available natural products to improve
hemorrhoids exhibits tremendous potential. These products are derived from nature, predominantly from plants, with a minor portion coming from animals, fungi, and algae. They have excellent coagulation pathway regulation, anti-inflammatory, antibacterial, and tissue regeneration activities. Therefore, we take the view that they are a class of potential hemorrhoid drugs, prevention products, and medication add-on ingredients. This article first reviews the factors contributing to the development of
hemorrhoids, types, primary symptoms, and the mechanisms of natural products for
hemorrhoids. Building on this foundation, we screened natural products with potential hemorrhoid improvement activity, including polyphenols and flavonoids, terpenes, polysaccharides, and other types.